Archaeologist and explorer Lara Croft (Angelina Jolie) is searching in the waters off the Greek Island of Santorini, after an earthquake, that may have revealed the Lunar Temple of Alexander the Great. Sunken underwater for centuries, the temple holds many treasures.
Lara has made perhaps the most important archaeological discovery in history: an orb that leads to the mythical Pandora’s Box.
After locating the map, stolen from her by Chen Lo (Yam), the leader of a Chinese crime syndicate, she learns that he is working for Jonathan Reiss (Ciarán Hinds), an evil scientist who deals in killer viruses and hopes to sell the secrets of the box as the ultimate weapon.
Recruited by British Intelligence to get the orb back from Reiss, Lara recruits Terry Sheridan (Gerard Butler), a British marine turned mercenary (and her former love interest) to help.
The two embark on an adventure that spans continents in an attempt to regain the orb…